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GRXCR1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | A8MXD5 |
| Other Accession | Q50H32, NP_001073945.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32294 Da |
| Antigen Region | 83-112 aa |
| Gene ID | 389207 |
|---|---|
| Other Names | Glutaredoxin domain-containing cysteine-rich protein 1, GRXCR1, DFNB25 |
| Target/Specificity | This GRXCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human GRXCR1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRXCR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GRXCR1 |
|---|---|
| Synonyms | DFNB25 |
| Function | May play a role in actin filament architecture in developing stereocilia of sensory cells. |
| Cellular Location | Cell projection, stereocilium. Cell projection, microvillus. Cell projection, kinocilium. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia. |
| Tissue Location | Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells.
References
Schraders, M., et al. Am. J. Hum. Genet. 86(2):138-147(2010)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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