|Application ||WB, E|
|Other Accession||Q50H32, NP_001073945.1|
|Calculated MW||32294 Da|
|Antigen Region||83-112 aa|
|Other Names||Glutaredoxin domain-containing cysteine-rich protein 1, GRXCR1, DFNB25|
|Target/Specificity||This GRXCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human GRXCR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRXCR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in actin filament architecture in developing stereocilia of sensory cells.|
|Cellular Location||Cell projection, stereocilium. Cell projection, microvillus. Cell projection, kinocilium. Note=In the inner ear, localized to stereocilia, apical microvilli of sensory cells and kinocilia|
|Tissue Location||Expressed at low levels in adult lung, brain and duodenum with moderate levels in testis. Highly expressed in fetal cochlea.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells.
Schraders, M., et al. Am. J. Hum. Genet. 86(2):138-147(2010)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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