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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   STAMBP Antibody (C-term)   

STAMBP Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - STAMBP Antibody (C-term) AP12698b
    STAMBP Antibody (C-term) (Cat. #AP12698b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the STAMBP antibody detected the STAMBP protein (arrow).
  • WB - STAMBP Antibody (C-term) AP12698b
    STAMBP Antibody (C-term) (Cat. #AP12698b) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the STAMBP antibody detected the STAMBP protein (arrow).
  • IHC-P - STAMBP Antibody (C-term) AP12698b
    STAMBP Antibody (C-term) (Cat. #AP12698b)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STAMBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95630
Other Accession NP_964010.1, NP_006454.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48077 Da
Antigen Region 355-383 aa
Additional Information
Gene ID 10617
Other Names STAM-binding protein, 3419-, Associated molecule with the SH3 domain of STAM, Endosome-associated ubiquitin isopeptidase, STAMBP, AMSH
Target/Specificity This STAMBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human STAMBP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTAMBP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms AMSH
Function Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Cellular Location Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.


Sierra, M.I., et al. J. Biol. Chem. 285(18):13990-14004(2010)
Hasdemir, B., et al. J. Biol. Chem. 284(41):28453-28466(2009)
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Wang, P., et al. BMC Genomics 10, 518 (2009) :
Sato, Y., et al. Nature 455(7211):358-362(2008)

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$ 295.00
$ 99.00
Cat# AP12698b
(40 western blots)
Availability: In Stock
Bulk Size
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