- CITATIONS: 2
|Application ||WB, IHC-P, E|
|Other Accession||P13444, Q91X83, Q2KJC6, NP_000420.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||43648 Da|
|Antigen Region||107-136 aa|
|Other Names||S-adenosylmethionine synthase isoform type-1, AdoMet synthase 1, Methionine adenosyltransferase 1, MAT 1, Methionine adenosyltransferase I/III, MAT-I/III, MAT1A, AMS1, MATA1|
|Target/Specificity||This MAT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human MAT1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAT1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.|
|Tissue Location||Expressed in liver.|
Provided below are standard protocols that you may find useful for product applications.
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wu, S.M., et al. Cell. Mol. Life Sci. 67(11):1831-1843(2010)
Lai, C.Q., et al. Am. J. Clin. Nutr. 91(5):1377-1386(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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