|Application ||WB, E|
|Calculated MW||92167 Da|
|Antigen Region||26-55 aa|
|Other Names||Cyclic nucleotide-gated cation channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-3, CNG channel beta-3, CNGB3|
|Target/Specificity||This CNGB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human CNGB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNGB3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed specifically in the retina.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease.
Komaromy, A.M., et al. Hum. Mol. Genet. 19(13):2581-2593(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Thiadens, A.A., et al. Ophthalmology 117(4):825-830(2010)
Azam, M., et al. Mol. Vis. 16, 774-781 (2010) :
Peng, C., et al. J. Biol. Chem. 278(36):34533-34540(2003)
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