|Application ||WB, E|
|Other Accession||P70512, O08755, NP_004489.1|
|Calculated MW||51023 Da|
|Antigen Region||356-385 aa|
|Other Names||Hepatocyte nuclear factor 6, HNF-6, One cut domain family member 1, One cut homeobox 1, ONECUT1, HNF6, HNF6A|
|Target/Specificity||This ONECUT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 356-385 amino acids from the C-terminal region of human ONECUT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ONECUT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.|
|Tissue Location||Highly expressed in liver; lower expression in testis and skin|
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Provided below are standard protocols that you may find useful for product applications.
ONECUT1 is a transcriptional activator. It binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. It is important for liver genes transcription.
Lee, Y.S., et al. Biochem. J. 413(3):559-569(2008)
Jiang, X., et al. Oncol. Rep. 19(1):157-163(2008)
Lehner, F., et al. FASEB J. 21(7):1445-1462(2007)
Rausa, F.M. III, et al. J. Biol. Chem. 279(41):43070-43076(2004)
Thomas, H., et al. Nucleic Acids Res. 32 (19), E150 (2004) :
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