- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||21632 Da|
|Antigen Region||16-45 aa|
|Other Names||Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6, TM4SF1, M3S1, TAAL6|
|Target/Specificity||This TM4SF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human TM4SF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TM4SF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.
Gordon, G.J., et al. J. Natl. Cancer Inst. 101(9):678-686(2009)
Lekishvili, T., et al. J. Cell. Sci. 121 (PT 5), 685-694 (2008) :
Stelzl, U., et al. Cell 122(6):957-968(2005)
Chang, Y.W., et al. Int. J. Cancer 116(2):243-252(2005)
Kao, Y.R., et al. Clin. Cancer Res. 9(7):2807-2816(2003)
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