|Application ||WB, E|
|Other Accession||Q8K013, NP_149098.2, NP_001036182.1|
|Calculated MW||42933 Da|
|Antigen Region||243-271 aa|
|Other Names||GTP-binding protein 10, Protein obg homolog 2, ObgH2, GTPBP10, OBGH2|
|Target/Specificity||This GTPBP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-271 amino acids from the C-terminal region of human GTPBP10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTPBP10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.|
|Cellular Location||Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase Gradually re-assembles into the nucleolus at late anaphase to telophase|
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Provided below are standard protocols that you may find useful for product applications.
Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).
Hirano, Y., et al. Genes Cells 11(11):1295-1304(2006)
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