|Application ||WB, E|
|Calculated MW||71896 Da|
|Antigen Region||36-65 aa|
|Other Names||ATP-binding cassette sub-family G member 4, ABCG4, WHITE2|
|Target/Specificity||This ABCG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human ABCG4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ABCG4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in macrophage lipid homeostasis.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in brain tissues with the exception of the spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Koshiba, S., et al. Xenobiotica 38 (7-8), 863-888 (2008) :
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