|Application ||IHC-P, WB, E|
|Other Accession||Q7TQM3, Q91V87, NP_001004358.1|
|Calculated MW||54537 Da|
|Antigen Region||131-160 aa|
|Other Names||Fibroblast growth factor receptor-like 1, FGF receptor-like protein 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5, FGFR-5, FGFRL1, FGFR5, FHFR|
|Target/Specificity||This FGFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human FGFRL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGFRL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a negative effect on cell proliferation.|
|Cellular Location||Membrane; Single-pass type I membrane protein Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles|
|Tissue Location||Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
LopezJimenez, N., et al. Hum. Genet. 127(3):325-336(2010)
Steinberg, F., et al. J. Biol. Chem. 285(3):2193-2202(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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