|Application ||WB, IHC-P, E|
|Calculated MW||80244 Da|
|Antigen Region||277-306 aa|
|Other Names||Sarcoplasmic reticulum histidine-rich calcium-binding protein, HRC, HCP|
|Target/Specificity||This HRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the Central region of human HRC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HRC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.|
|Cellular Location||Sarcoplasmic reticulum lumen.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR.
Arvanitis, D.A., et al. Eur. Heart J. 29(20):2514-2525(2008)
Arvanitis, D.A., et al. Am. J. Physiol. Heart Circ. Physiol. 293 (3), H1581-H1589 (2007) :
Fan, G.C., et al. Am. J. Physiol. Heart Circ. Physiol. 287 (4), H1705-H1711 (2004) :
Anderson, J.P., et al. Mol. Cell. Biol. 24(9):3757-3768(2004)
Adkins, J.N., et al. Mol. Cell Proteomics 1(12):947-955(2002)
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