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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NKX2-2 Antibody (Center)   

NKX2-2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NKX2-2 Antibody (Center) AP12730c
    NKX2-2 Antibody (Center) (Cat. #AP12730c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NKX2-2 antibody detected the NKX2-2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95096
Other Accession NP_002500.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30133 Da
Antigen Region 2-2 aa
Additional Information
Gene ID 4821
Other Names Homeobox protein Nkx-22, Homeobox protein NK-2 homolog B, NKX2-2, NKX22, NKX2B
Target/Specificity This NKX2-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-120 amino acids from the Central region of human NKX2-2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNKX2-2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX2-2
Synonyms NKX2.2, NKX2B
Function Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}
Research Areas
Citations (0)

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The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.


Wang, Y.C., et al. J. Surg. Res. 163(1):47-51(2010)
Wang, Y.C., et al. Endocr. Relat. Cancer 16(1):267-279(2009)
Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
Owen, L.A., et al. PLoS ONE 3 (4), E1965 (2008) :
Pauls, S., et al. Dev. Biol. 304(2):875-890(2007)

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$ 295.00
$ 99.00
Cat# AP12730c
(40 western blots)
Availability: In Stock
Bulk Size
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