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NKX2-2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95096 |
| Other Accession | NP_002500.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30133 Da |
| Antigen Region | 2-2 aa |
| Gene ID | 4821 |
|---|---|
| Other Names | Homeobox protein Nkx-22, Homeobox protein NK-2 homolog B, NKX2-2, NKX22, NKX2B |
| Target/Specificity | This NKX2-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-120 amino acids from the Central region of human NKX2-2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NKX2-2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKX2-2 |
|---|---|
| Synonyms | NKX2.2, NKX2B |
| Function | Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
References
Wang, Y.C., et al. J. Surg. Res. 163(1):47-51(2010)
Wang, Y.C., et al. Endocr. Relat. Cancer 16(1):267-279(2009)
Chen, M., et al. J. Biol. Chem. 284(3):1484-1494(2009)
Owen, L.A., et al. PLoS ONE 3 (4), E1965 (2008) :
Pauls, S., et al. Dev. Biol. 304(2):875-890(2007)
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