- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||53511 Da|
|Antigen Region||442-471 aa|
|Other Names||Keratin, type I cytoskeletal 12, Cytokeratin-12, CK-12, Keratin-12, K12, KRT12|
|Target/Specificity||This KRT12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-471 amino acids from the C-terminal region of human KRT12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KRT12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).|
|Tissue Location||Cornea specific..|
Provided below are standard protocols that you may find useful for product applications.
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy.
Clausen, I., et al. Mol. Vis. 16, 954-960 (2010) :
Seto, T., et al. Jpn. J. Ophthalmol. 52(3):224-226(2008)
Nielsen, K., et al. Cornea 27(1):100-102(2008)
Sullivan, L.S., et al. Mol. Vis. 13, 975-980 (2007) :
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
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