|Application ||WB, IHC-P, E|
|Calculated MW||44894 Da|
|Antigen Region||187-216 aa|
|Other Names||Signal-transducing adaptor protein 2, STAP-2, Breast tumor kinase substrate, BRK substrate, STAP2, BKS|
|Target/Specificity||This STAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of human STAP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Sekine, Y., et al. J. Immunol. 183(12):7966-7974(2009)
Sekine, Y., et al. Biochem. Biophys. Res. Commun. 384(2):187-192(2009)
Ikeda, O., et al. Biochem. Biophys. Res. Commun. 384(1):71-75(2009)
Ikeda, O., et al. Mol. Cell. Biol. 28(16):5027-5042(2008)
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