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RPP38 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P78345 |
| Other Accession | Q32LC1, NP_001091059.1, NP_006405.2, NP_892117.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31834 Da |
| Antigen Region | 248-277 aa |
| Gene ID | 10557 |
|---|---|
| Other Names | Ribonuclease P protein subunit p38, RNaseP protein p38, RPP38 |
| Target/Specificity | This RPP38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-277 amino acids from the C-terminal region of human RPP38. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RPP38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RPP38 |
|---|---|
| Function | Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences (PubMed:28115465). |
| Cellular Location | Nucleus, nucleolus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Welting, T.J., et al. Nucleic Acids Res. 32(7):2138-2146(2004)
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