- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
NPHP3 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AP12751a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12751a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
NPHP3 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q7Z494 |
| Other Accession | Q6AZT7, P0CI65, NP_694972.3 |
| Reactivity | Human |
| Predicted | Xenopus, Zebrafish |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 150864 Da |
NPHP3 Antibody (N-term) - Additional info | |
| Gene ID 27031 | |
| Other Names NPHP3; KIAA2000; Nephrocystin-3 | |
| Target/Specificity This NPHP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-181 amino acids from the N-terminal region of human NPHP3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NPHP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NPHP3 Antibody (N-term) - Protein Information | |
| Name NPHP3 | |
| Synonyms KIAA2000 | |
| Function Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements | |
| Cellular Location Cell projection, cilium. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus | |
| Tissue Location Widely expressed at low level. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas Expressed at very low level in brain and lung | |
NPHP3 Antibody (N-term) - Related products
NPHP3 Antibody (N-term) - Application data
-
NPHP3 Antibody (N-term) (Cat. #AP12751a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the NPHP3 antibody detected the NPHP3 protein (arrow).
-
NPHP3 Antibody (N-term) (Cat. #AP12751a)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NPHP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
NPHP3 Antibody (N-term) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin and may function in renal tubular development and function. Mutations in this gene are associated with nephronophthisis type 3. Multiple splice variants have been described but their full-length nature has not been determined.
REFERENCES
Simpson, M.A., et al. Am. J. Kidney Dis. 53(5):790-795(2009) Tory, K., et al. Kidney Int. 75(8):839-847(2009) Bergmann, C., et al. Am. J. Hum. Genet. 82(4):959-970(2008) Hoefele, J., et al. J. Am. Soc. Nephrol. 18(10):2789-2795(2007) Leipe, D.D., et al. J. Mol. Biol. 343(1):1-28(2004)
