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NPHP3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NPHP3 Antibody (N-term) AP12751a
    NPHP3 Antibody (N-term) (Cat. #AP12751a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the NPHP3 antibody detected the NPHP3 protein (arrow).
  • IHC-P - NPHP3 Antibody (N-term) AP12751a
    NPHP3 Antibody (N-term) (Cat. #AP12751a)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NPHP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z494
Other Accession Q6AZT7, P0CI65, NP_694972.3
Reactivity Human
Predicted Zebrafish, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 150864 Da
Antigen Region 144-173 aa
Additional Information
Gene ID 27031
Other Names Nephrocystin-3, NPHP3, KIAA2000
Target/Specificity This NPHP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human NPHP3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNPHP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NPHP3
Synonyms KIAA2000
Function Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Cellular Location Cell projection, cilium Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N- terminus
Tissue Location Widely expressed at low level. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas Expressed at very low level in brain and lung
Citations (0)

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This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin and may function in renal tubular development and function. Mutations in this gene are associated with nephronophthisis type 3. Multiple splice variants have been described but their full-length nature has not been determined.


Simpson, M.A., et al. Am. J. Kidney Dis. 53(5):790-795(2009)
Tory, K., et al. Kidney Int. 75(8):839-847(2009)
Bergmann, C., et al. Am. J. Hum. Genet. 82(4):959-970(2008)
Hoefele, J., et al. J. Am. Soc. Nephrol. 18(10):2789-2795(2007)
Leipe, D.D., et al. J. Mol. Biol. 343(1):1-28(2004)

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$ 295.00
$ 99.00
Cat# AP12751a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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