|Application ||WB, FC, E|
|Other Accession||P67937, NP_003281.1, P02561|
|Calculated MW||28522 Da|
|Antigen Region||26-54 aa|
|Other Names||Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4|
|Target/Specificity||This TPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TPM4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPM4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Vlahovich, N., et al. Cell Motil. Cytoskeleton 65(1):73-85(2008)
Montesano Gesualdi, N., et al. Free Radic. Res. 40(5):467-476(2006)
Hossain, M.M., et al. J. Biol. Chem. 280(51):42442-42453(2005)
Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)
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