|Application ||WB, E|
|Other Accession||NP_060248.2, NP_075447.1|
|Calculated MW||161613 Da|
|Antigen Region||188-217 aa|
|Other Names||Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, NSD3|
|Target/Specificity||This WHSC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the N-terminal region of human WHSC1L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WHSC1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.|
|Cellular Location||Nucleus. Chromosome|
|Tissue Location||Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung|
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Provided below are standard protocols that you may find useful for product applications.
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.
Zhou, Z., et al. Biochem. Biophys. Res. Commun. 398(3):565-570(2010)
Kim, S.M., et al. Biochem. Biophys. Res. Commun. 345(1):318-323(2006)
Tonon, G., et al. Proc. Natl. Acad. Sci. U.S.A. 102(27):9625-9630(2005)
Rosati, R., et al. Blood 99(10):3857-3860(2002)
Stec, I., et al. Genomics 76 (1-3), 5-8 (2001) :
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