SPOPL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, FC, E |
---|---|
Primary Accession | Q6IQ16 |
Other Accession | NP_001001664.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 44647 Da |
Antigen Region | 221-249 aa |
Gene ID | 339745 |
---|---|
Other Names | Speckle-type POZ protein-like, HIB homolog 2, Roadkill homolog 2, SPOPL |
Target/Specificity | This SPOPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of human SPOPL. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SPOPL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SPOPL |
---|---|
Function | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes that contain SPOP. |
Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
In complex with a cullin, may act in ubiquitination and proteasomal degradation processes (By similarity).
References
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Zhang, Q., et al. Dev. Cell 10(6):719-729(2006)
Kent, D., et al. Development 133(10):2001-2010(2006)
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