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ALKBH4 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ALKBH4 Antibody (Center) AP12774C
    ALKBH4 Antibody (Center) (Cat. #AP12774c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ALKBH4 antibody detected the ALKBH4 protein (arrow).
    detail
  • WB - ALKBH4 Antibody (Center) AP12774C
    ALKBH4 Antibody (Center) (Cat. #AP12774c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the ALKBH4 antibody detected the ALKBH4 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NXW9
Other Accession NP_060091.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33838 Da
Antigen Region 88-117 aa
Additional Information
Gene ID 54784
Other Names Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, 11411-, Alkylated DNA repair protein alkB homolog 4, ALKBH4, ABH4
Target/Specificity This ALKBH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human ALKBH4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALKBH4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALKBH4 {ECO:0000303|PubMed:21166655, ECO:0000312|HGNC:HGNC:21900}
Function Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).
Cellular Location Cytoplasm. Nucleus. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9D8F1}. Midbody. Note=Associates with the contractile ring and midbody.
Tissue Location Widely expressed, with highest expression in pancreas, ovary and spleen.
Citations (0)
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Background

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

References

Tsujikawa, K., et al. J. Cell. Mol. Med. 11(5):1105-1116(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 365.00
$ 140.00
Cat# AP12774C
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