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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   XYLT1 Antibody (N-term)   

XYLT1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - XYLT1 Antibody (N-term) AP12779a
    XYLT1 Antibody (N-term) (Cat. #AP12779a) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the XYLT1 antibody detected the XYLT1 protein (arrow).
  • FC - XYLT1 Antibody (N-term) AP12779a
    XYLT1 Antibody (N-term) (Cat. #AP12779a) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86Y38
Other Accession Q9EPI1, Q811B1, NP_071449.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107569 Da
Antigen Region 126-155 aa
Additional Information
Gene ID 64131
Other Names Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I, XYLT1, XT1
Target/Specificity This XYLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human XYLT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXYLT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XYLT1
Synonyms XT1
Function Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein Golgi apparatus membrane; Single- pass type II membrane protein. Secreted. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted
Tissue Location Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
Research Areas
Citations (0)

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This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Muller, B., et al. J. Biol. Chem. 284(45):30775-30782(2009)
Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)
Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :
Schon, S., et al. J. Med. Genet. 43(9):745-749(2006)

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Cat# AP12779a
(40 western blots)
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