|Application ||WB, FC, E|
|Other Accession||Q9EPI1, Q811B1, NP_071449.1|
|Calculated MW||107569 Da|
|Antigen Region||126-155 aa|
|Other Names||Xylosyltransferase 1, Peptide O-xylosyltransferase 1, Xylosyltransferase I, XT-I, XylT-I, XYLT1, XT1|
|Target/Specificity||This XYLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the N-terminal region of human XYLT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XYLT1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein Golgi apparatus membrane; Single- pass type II membrane protein. Secreted. Note=Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, suggesting that it can be secreted|
|Tissue Location||Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Muller, B., et al. J. Biol. Chem. 284(45):30775-30782(2009)
Ponighaus, C., et al. Am. J. Hypertens. 22(4):432-436(2009)
Ambrosius, M., et al. Clin. Biochem. 42 (1-2), 1-4 (2009) :
Schon, S., et al. J. Med. Genet. 43(9):745-749(2006)
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