|Application ||WB, E|
|Other Accession||Q80Z38, NP_036441.2|
|Calculated MW||158822 Da|
|Antigen Region||879-908 aa|
|Other Names||SH3 and multiple ankyrin repeat domains protein 2, Shank2, Cortactin-binding protein 1, CortBP1, Proline-rich synapse-associated protein 1, SHANK2, CORTBP1, KIAA1022, PROSAP1|
|Target/Specificity||This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SHANK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CORTBP1, KIAA1022, PROSAP1|
|Function||Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.|
|Cellular Location||Apical cell membrane. Cytoplasm. Cell junction, synapse Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, growth cone Cell projection, dendritic spine. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).|
|Tissue Location||Isoform 3 is present in epithelial colonic cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].
Pinto, D., et al. Nature 466(7304):368-372(2010)
Berkel, S., et al. Nat. Genet. 42(6):489-491(2010)
Lee, J.S., et al. J. Biol. Chem. 285(11):8104-8113(2010)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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