|Application ||WB, E|
|Other Accession||NP_001116137.1, NP_004651.2|
|Calculated MW||73154 Da|
|Antigen Region||90-119 aa|
|Other Names||ATP-dependent RNA helicase DDX3Y, DEAD box protein 3, Y-chromosomal, DDX3Y, DBY|
|Target/Specificity||This DDX3Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human DDX3Y.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDX3Y Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable ATP-dependent RNA helicase. May play a role in spermatogenesis.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner|
|Tissue Location||Testis-specific. Expressed predominantly in spermatogonia.|
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Provided below are standard protocols that you may find useful for product applications.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified.
Rosinski, K.V., et al. Blood 111(9):4817-4826(2008)
Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)
Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005) :
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Ficarro, S.B., et al. Rapid Commun. Mass Spectrom. 19(1):57-71(2005)
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