|Application ||WB, E|
|Calculated MW||20682 Da|
|Antigen Region||17-45 aa|
|Other Names||GTPase RhebL1, Ras homolog enriched in brain like-1 c, RhebL1c, Ras homolog enriched in brain-like protein 1, Rheb-like protein 1, Rheb2, RHEBL1|
|Target/Specificity||This RHEBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human RHEBL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RHEBL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.|
|Cellular Location||Endomembrane system; Lipid-anchor; Cytoplasmic side Cytoplasm|
|Tissue Location||Ubiquitously expressed. Expression increased at least 2-fold in several tumor cell lines|
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Provided below are standard protocols that you may find useful for product applications.
RHEBL1 binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through FRAP1, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
Yuan, J., et al. Mol. Biol. Rep. 32(4):205-214(2005)
Tee, A.R., et al. FEBS Lett. 579(21):4763-4768(2005)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Tabancay, A.P. Jr., et al. J. Biol. Chem. 278(41):39921-39930(2003)
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