|Application ||WB, IHC-P, E|
|Calculated MW||103010 Da|
|Antigen Region||585-614 aa|
|Other Names||Sodium/calcium exchanger 3, Na(+)/Ca(2+)-exchange protein 3, Solute carrier family 8 member 3, SLC8A3, NCX3|
|Target/Specificity||This SLC8A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 585-614 amino acids from the C-terminal region of human SLC8A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC8A3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Pulina, M.V., et al. J. Biol. Chem. 281(28):19645-19654(2006)
Gomez-Villafuertes, R., et al. J. Neurosci. 25(47):10822-10830(2005)
Lindgren, R.M., et al. Gene 348, 143-155 (2005) :
Gabellini, N. Mol. Neurobiol. 30(1):91-116(2004)
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