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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   COPS7A Antibody (C-term)   

COPS7A Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - COPS7A Antibody (C-term) AP12810b
    COPS7A Antibody (C-term) (Cat. #AP12810b) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the COPS7A antibody detected the COPS7A protein (arrow).
  • IHC-P - COPS7A Antibody (C-term) AP12810b
    COPS7A Antibody (C-term) (Cat. #AP12810b)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COPS7A Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBW8
Other Accession Q9CZ04, NP_057403.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30277 Da
Antigen Region 237-266 aa
Additional Information
Gene ID 50813
Other Names COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Target/Specificity This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOPS7A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COPS7A
Synonyms CSN7A, DERP10
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
Research Areas
Citations (0)

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Background

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

References

Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Obuse, C., et al. Nat. Cell Biol. 6(11):1135-1141(2004)
Wolf, D.A., et al. Nat. Cell Biol. 5(12):1029-1033(2003)
Groisman, R., et al. Cell 113(3):357-367(2003)

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$ 295.00
$ 99.00
Cat# AP12810b
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(40 western blots)
Availability: In Stock
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