|Application ||WB, E|
|Other Accession||NP_001180237.1, NP_116261.1|
|Calculated MW||61857 Da|
|Antigen Region||296-325 aa|
|Other Names||Synaptotagmin-like protein 1, Exophilin-7, Protein JFC1, SYTL1, SLP1|
|Target/Specificity||This SYTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SYTL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYTL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein tightly bound to the cytoplasmic side of cellular membranes|
|Tissue Location||Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).|
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Provided below are standard protocols that you may find useful for product applications.
SYTL1 may play a role in vesicle trafficking (By similarity). It binds phosphatidylinositol 3,4,5-triphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
Neumuller, O., et al. Blood 114(7):1396-1404(2009)
Holt, O., et al. Traffic 9(4):446-457(2008)
Schmid, M., et al. J. Leukoc. Biol. 81(4):907-915(2007)
Johnson, J.L., et al. Biochem. J. 391 (PT 3), 699-710 (2005) :
Catz, S.D., et al. Biochem. J. 367 (PT 3), 791-799 (2002) :
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