|Application ||WB, E|
|Other Accession||Q8BI21, NP_919311.1, NP_919313.1, NP_919310.1, NP_919309.1, NP_073618.3|
|Calculated MW||57595 Da|
|Antigen Region||40-69 aa|
|Other Names||E3 ubiquitin-protein ligase RNF38, 632-, RING finger protein 38, RNF38|
|Target/Specificity||This RNF38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human RNF38.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF38 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.|
|Tissue Location||Widely expressed with highest levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Eisenberg, I., et al. Biochem. Biophys. Res. Commun. 294(5):1169-1176(2002)
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