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DSN1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H410 |
| Other Accession | NP_001138787.1, NP_079194.3, NP_001138788.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40067 Da |
| Antigen Region | 257-286 aa |
| Gene ID | 79980 |
|---|---|
| Other Names | Kinetochore-associated protein DSN1 homolog, DSN1, C20orf172, MIS13 |
| Target/Specificity | This DSN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human DSN1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DSN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DSN1 |
|---|---|
| Synonyms | C20orf172, MIS13 |
| Function | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore Note=Associated with the kinetochore. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants.
References
Yang, Y., et al. J. Biol. Chem. 283(39):26726-26736(2008)
Cheeseman, I.M., et al. Nat. Rev. Mol. Cell Biol. 9(1):33-46(2008)
Kiyomitsu, T., et al. Dev. Cell 13(5):663-676(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Kline, S.L., et al. J. Cell Biol. 173(1):9-17(2006)
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