|Application ||WB, IHC-P, FC, E|
|Calculated MW||23794 Da|
|Antigen Region||26-55 aa|
|Other Names||StAR-related lipid transfer protein 5, START domain-containing protein 5, StARD5, STARD5|
|Target/Specificity||This STARD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human STARD5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STARD5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Chen, Y.C., et al. Am. J. Physiol. Renal Physiol. 297 (2), F380-F388 (2009) :
Rodriguez-Agudo, D., et al. J. Lipid Res. 47(6):1168-1175(2006)
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