SMCP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P49901 |
Other Accession | NP_109588.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 12767 Da |
Antigen Region | 68-97 aa |
Gene ID | 4184 |
---|---|
Other Names | Sperm mitochondrial-associated cysteine-rich protein, SMCP, MCS, MCSP |
Target/Specificity | This SMCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the C-terminal region of human SMCP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SMCP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SMCP |
---|---|
Synonyms | MCS, MCSP |
Function | Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). |
Cellular Location | Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. |
Tissue Location | Testis. Is selectively expressed in the spermatids of seminiferous tubules. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.
References
Yatsenko, A.N., et al. Hum. Mol. Genet. 15(23):3411-3419(2006)
Hawthorne, S.K., et al. Genomics 87(3):382-391(2006)
Behne, D., et al. Annu. Rev. Nutr. 21, 453-473 (2001) :
Cataldo, L., et al. Mol. Reprod. Dev. 45(3):320-331(1996)
Aho, H., et al. Genomics 32(2):184-190(1996)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.