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SUMO2 Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP1282a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 1
- Reviews
- Protocols
- Backgrounds
SUMO2 Antibody (C-term) - Product info | |
| Application | IHC, WB
|
| Primary Accession | P61956 |
| Other Accession | Q7SZ22, Q5XIF4, Q9Z172, P55854, Q6DI05, Q5ZHQ1, Q17QV3, P61959, P61958, P61957, Q2PFW2, Q6DHL4, Q6LDZ8, Q5ZJM9, P61955, Q6NV25, Q6GPW2, Q7ZTK7 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Hamster, Mouse, Pig, Monkey, Rat, Xenopus, Zebrafish |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 10871 Da |
SUMO2 Antibody (C-term) - Additional info | |
| Gene ID 6613 | |
| Other Names SUMO2; SMT3A; SMT3H2; Small ubiquitin-related modifier 2; HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3A | |
| Target/Specificity This SUMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SUMO2. | |
| Dilution IHC~~1:50~100 WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SUMO2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SUMO2 Antibody (C-term) - Protein Information | |
| Name SUMO2 | |
| Synonyms SMT3A, SMT3H2 | |
| Function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins | |
| Cellular Location Nucleus. Note=Nuclear bodies. | |
| Tissue Location Broadly expressed. | |
SUMO2 Antibody (C-term) - Related products
AP1223a: SUMO2/3 Antibody (N-term)
AP1223f: SUMO2/3 Antibody (N-term M1)
AP1282a: SUMO2 Antibody (C-term)
RI15170: SUMO2 predesign siRNA
DC04357: Human SUMO2 cDNA Clone
BP1223a: SUMO2/3 Antibody (N-term) Blocking Peptide
SUMO2 Antibody (C-term) - Application data
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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The SUMO2 C-term Antibody (Cat.#AP1282a) is used in Western blot to detect SUMO2 in GST-SUMO2 fusion protein (lane 1) and HL60 cell lysate (lane 2).
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Western blot analysis of SUMO2 (arrow) using rabbit polyclonal SUMO2 Antibody (Cat.#AP1282a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SUMO2 gene.
SUMO2 Antibody (C-term) - Research Areas
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BACKGROUND
SUMO2 is a member of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
REFERENCES
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Lapenta, V., et al., Genomics 40(2):362-366 (1997).
