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UNC45A Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H3U1 |
| Other Accession | NP_061141.2, NP_001034764.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103077 Da |
| Antigen Region | 146-174 aa |
| Gene ID | 55898 |
|---|---|
| Other Names | Protein unc-45 homolog A, Unc-45A, GCUNC-45, Smooth muscle cell-associated protein 1, SMAP-1, UNC45A, SMAP1 |
| Target/Specificity | This UNC45A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-174 amino acids from the N-terminal region of human UNC45A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UNC45A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UNC45A |
|---|---|
| Synonyms | SMAP1 |
| Function | Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Predominant in the perinuclear region. Little protein in the nucleus |
| Tissue Location | Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).
References
Chadli, A., et al. J. Biol. Chem. 283(15):9509-9512(2008)
Bazzaro, M., et al. Am. J. Pathol. 171(5):1640-1649(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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