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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PELI2 Antibody (N-term)   

PELI2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PELI2 Antibody (N-term) AP12838A
    PELI2 Antibody (N-term) (Cat. #AP12838a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PELI2 antibody detected the PELI2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HAT8
Other Accession Q8BST6, NP_067078.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46435 Da
Antigen Region 15-43 aa
Additional Information
Gene ID 57161
Other Names E3 ubiquitin-protein ligase pellino homolog 2, Pellino-2, 632-, PELI2
Target/Specificity This PELI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human PELI2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPELI2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PELI2
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Research Areas
Citations (0)

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Scaffold protein which probably links Toll-like receptors (TLRs) to basic cellular processes via its interaction with the complex containing IRAK kinases and TRAF6. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ordureau, A., et al. Biochem. J. 409(1):43-52(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Liu, Y., et al. J. Biol. Chem. 279(36):37436-37444(2004)
Strelow, A., et al. FEBS Lett. 547 (1-3), 157-161 (2003) :

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Cat# AP12838A
(40 western blots)
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