|Application ||WB, IHC-P, E|
|Other Accession||Q91YJ2, NP_003785.1|
|Calculated MW||51909 Da|
|Antigen Region||391-420 aa|
|Other Names||Sorting nexin-4, SNX4|
|Target/Specificity||This SNX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human SNX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNX4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.|
|Cellular Location||Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC)|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq].
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Skanland, S.S., et al. PLoS ONE 4 (6), E5935 (2009) :
Traer, C.J., et al. Nat. Cell Biol. 9(12):1370-1380(2007)
Skanland, S.S., et al. Traffic 8(3):297-309(2007)
Leprince, C., et al. J. Cell. Sci. 116 (PT 10), 1937-1948 (2003) :
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