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SNX4 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SNX4 Antibody (C-term) AP12854b
    SNX4 Antibody (C-term) (Cat. #AP12854b) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the SNX4 antibody detected the SNX4 protein (arrow).
    detail
  • IHC-P - SNX4 Antibody (C-term) AP12854b
    SNX4 Antibody (C-term) (Cat. #AP12854b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SNX4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession O95219
Other Accession Q91YJ2, NP_003785.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51909 Da
Antigen Region 391-420 aa
Additional Information
Gene ID 8723
Other Names Sorting nexin-4, SNX4
Target/Specificity This SNX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human SNX4.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNX4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNX4 {ECO:0000303|PubMed:9819414, ECO:0000312|HGNC:HGNC:11175}
Function Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).
Cellular Location Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC).
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq].

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Skanland, S.S., et al. PLoS ONE 4 (6), E5935 (2009) :
Traer, C.J., et al. Nat. Cell Biol. 9(12):1370-1380(2007)
Skanland, S.S., et al. Traffic 8(3):297-309(2007)
Leprince, C., et al. J. Cell. Sci. 116 (PT 10), 1937-1948 (2003) :

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$ 182.50
$ 70.00
Cat# AP12854b
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