|Application ||WB, E|
|Calculated MW||90398 Da|
|Antigen Region||639-668 aa|
|Other Names||Phosphoinositide 3-kinase adapter protein 1, B-cell adapter for phosphoinositide 3-kinase, B-cell phosphoinositide 3-kinase adapter protein 1, PIK3AP1, BCAP|
|Target/Specificity||This PIK3AP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 639-668 amino acids from the C-terminal region of human PIK3AP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIK3AP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein|
|Tissue Location||Expressed in natural killer (NK) cells.|
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Provided below are standard protocols that you may find useful for product applications.
PIK3AP1 is involved in the activation of phosphoinositide 3-kinase (PI3K) in B-cells and in natural killer (NK) cells. Couples B-cell antigen receptor (BCR) to PI3K activation by providing a docking site for the PI3K subunit PIK3R1, which contributes to B-cell development. Seems to have a complementary role with CD19 in PI3K activation (By similarity). May be involved in the survival of mature B cells via activation of REL (By similarity).
Koutros, S., et al. Cancer Res. 70(6):2389-2396(2010)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Maruoka, M., et al. FEBS Lett. 579(14):2986-2990(2005)
Okada, T., et al. Immunity 13(6):817-827(2000)
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