|Application ||WB, IHC-P, E|
|Calculated MW||51815 Da|
|Antigen Region||21-50 aa|
|Other Names||Equilibrative nucleoside transporter 3, hENT3, Solute carrier family 29 member 3, SLC29A3, ENT3|
|Target/Specificity||This SLC29A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human SLC29A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC29A3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.|
|Cellular Location||Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface|
|Tissue Location||Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.
Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :
Kang, N., et al. J. Biol. Chem. 285(36):28343-28352(2010)
Li, X., et al. Zhongguo Fei Ai Za Zhi 13(5):458-463(2010)
Priya, T.P., et al. Br. J. Dermatol. 162(5):1132-1134(2010)
Cliffe, S.T., et al. Hum. Mol. Genet. 18(12):2257-2265(2009)
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