|Application ||WB, E|
|Other Accession||Q62511, NP_444251.1|
|Calculated MW||63445 Da|
|Antigen Region||216-245 aa|
|Other Names||E3 ubiquitin-protein ligase ZFP91, 632-, Zinc finger protein 757, Zinc finger protein 91 homolog, Zfp-91, ZFP91, ZNF757|
|Target/Specificity||This ZFP91 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human ZFP91.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZFP91 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.|
|Tissue Location||Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2.
Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400(4):581-586(2010)
Jin, X., et al. J. Biol. Chem. 285(40):30539-30547(2010)
Kiem, H.P., et al. Exp. Hematol. 38(9):819-822(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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