|Application ||WB, FC, E|
|Calculated MW||30850 Da|
|Antigen Region||195-224 aa|
|Other Names||Carbonyl reductase [NADPH] 3, NADPH-dependent carbonyl reductase 3, CBR3|
|Target/Specificity||This CBR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the C-terminal region of human CBR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).|
|Tissue Location||Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Zhang, J., et al. Pharm. Res. 26(9):2209-2215(2009)
Choi, J.Y., et al. Clin. Cancer Res. 15(16):5258-5266(2009)
Pilka, E.S., et al. PLoS ONE 4 (10), E7113 (2009) :
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