|Application ||WB, IHC-P, FC, E|
|Calculated MW||52286 Da|
|Antigen Region||210-240 aa|
|Other Names||Carboxypeptidase N catalytic chain, CPN, Anaphylatoxin inactivator, Arginine carboxypeptidase, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, Serum carboxypeptidase N, SCPN, CPN1, ACBP|
|Target/Specificity||This CPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 amino acids from the Central region of human CPN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Synthesized in the liver and secreted in plasma|
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Provided below are standard protocols that you may find useful for product applications.
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq].
Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010)
Du, X.Y., et al. J. Biol. Chem. 284(2):751-758(2009)
Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Skidgel, R.A., et al. Int. Immunopharmacol. 7(14):1888-1899(2007)
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