|Application ||WB, IHC-P, E|
|Calculated MW||37419 Da|
|Antigen Region||238-267 aa|
|Other Names||GMP reductase 1, Guanosine 5'-monophosphate oxidoreductase 1, Guanosine monophosphate reductase 1, GMPR, GMPR1|
|Target/Specificity||This GMPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-267 amino acids from the C-terminal region of human GMPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GMPR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.
Chasman, D.I., et al. PLoS Genet. 5 (11), E1000730 (2009) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Deng, Y., et al. Int. J. Biochem. Cell Biol. 34(9):1035-1050(2002)
Salvatore, D., et al. J. Biol. Chem. 273(47):31092-31096(1998)
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