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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   HMFG Antibody (C-term)   

HMFG Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HMFG Antibody (C-term) AP12888B
    HMFG Antibody (C-term) (Cat. #AP12888b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HMFG antibody detected the HMFG protein (arrow).
  • FC - HMFG Antibody (C-term) AP12888B
    HMFG Antibody (C-term) (Cat. #AP12888b) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q08431
Other Accession NP_005919.2, NP_001108086.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43123 Da
Antigen Region 316-345 aa
Additional Information
Gene ID 4240
Other Names Lactadherin, Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1, Lactadherin short form, Medin, MFGE8
Target/Specificity This HMFG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-345 amino acids from the C-terminal region of human HMFG.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHMFG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFGE8
Function Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.
Cellular Location Membrane; Peripheral membrane protein Secreted
Tissue Location Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas
Research Areas
Citations (0)

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Background

HMFG plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. Medin is the main constituent of aortic medial amyloid.

References

Yamaguchi, H., et al. Eur. J. Immunol. 40(6):1778-1785(2010)
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Hu, C.Y., et al. Lupus 18(8):676-681(2009)
Fu, Z., et al. Circ. Res. 104(12):1337-1346(2009)
Raymond, A., et al. J. Cell. Biochem. 106(6):957-966(2009)

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Cat# AP12888B
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(40 western blots)
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