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COCH Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12909c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12909c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
COCH Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | O43405 |
| Other Accession | Q5EA64, NP_004077.1, NP_001128530.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 59483 Da |
COCH Antibody (Center) - Additional info | |
| Gene ID 1690 | |
| Other Names COCH; COCH5B2; Cochlin; COCH-5B2 | |
| Target/Specificity This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-428 amino acids from the Central region of human COCH. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions COCH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
COCH Antibody (Center) - Protein Information | |
| Name COCH | |
| Synonyms COCH5B2 | |
| Function Plays a role in the control of cell shape and motility in the trabecular meshwork | |
| Cellular Location Secreted, extracellular space, extracellular matrix | |
| Tissue Location Expressed in inner ear structures; the cochlea and the vestibule | |
COCH Antibody (Center) - Related products
AP11332b: COCH Antibody (C-term)
AP12909c: COCH Antibody (Center)
COCH Antibody (Center) - Application data
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Western blot analysis of COCH (arrow) using rabbit polyclonal COCH Antibody (Center) (Cat. #AP12909c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COCH gene.
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COCH Antibody (Center) (Cat. #AP12909c)immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COCH Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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COCH Antibody (Center) (Cat. #AP12909c) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
COCH Antibody (Center) - Research Areas
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BACKGROUND
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].
REFERENCES
Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887(2010) Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010) Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010) Davila, S., et al. Genes Immun. 11(3):232-238(2010) Lee, E.S., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2060-2066(2010)
