|Application ||WB, E|
|Other Accession||Q14129, NP_150282.2|
|Calculated MW||24932 Da|
|Antigen Region||108-135 aa|
|Other Names||Protein DGCR6L, DiGeorge syndrome critical region 6-like protein, DGCR6L|
|Target/Specificity||This DGCR6L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-135 amino acids from the Central region of human DGCR6L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DGCR6L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.|
|Cellular Location||Nucleus. Note=Predominantly nuclear|
|Tissue Location||Widely expressed in fetal and adult tissues. Highest expression in liver, heart and skeletal muscle. Lower levels in pancreas and placenta. Weak expression in brain|
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Provided below are standard protocols that you may find useful for product applications.
This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome.
Li, X., et al. Int. J. Biochem. Cell Biol. 42(1):70-79(2010)
Pfuhl, T., et al. Hum. Genet. 117(1):70-80(2005)
Edelmann, L., et al. Genome Res. 11(2):208-217(2001)
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