|Application ||WB, E|
|Other Accession||NP_579805.1, NP_579803.1, NP_001991.1, NP_579813.1|
|Calculated MW||32265 Da|
|Antigen Region||58-84 aa|
|Other Names||Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89|
|Target/Specificity||This FCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-84 amino acids from the Central region of human FCAR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCAR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.|
|Cellular Location||Isoform A.1: Cell membrane; Single-pass type I membrane protein Isoform A.3: Cell membrane; Single-pass type I membrane protein Isoform B-delta-S2: Secreted.|
|Tissue Location||Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Vuong, M.T., et al. Kidney Int. (2010) In press :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Peng, M., et al. Cell Res. 20(2):223-237(2010)
Kobayashi, T., et al. J. Dent. Res. 88(12):1137-1141(2009)
van der Steen, L., et al. Gastroenterology 137(6):2018-2029(2009)
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