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FCAR Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FCAR Antibody (Center) AP12915c
    Western blot analysis of FCAR (arrow) using rabbit polyclonal FCAR Antibody (Center) (Cat. #AP12915c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FCAR gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24071
Other Accession NP_579805.1, NP_579803.1, NP_001991.1, NP_579813.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 58-84 aa
Additional Information
Other Names Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89
Target/Specificity This FCAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-84 amino acids from the Central region of human FCAR.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCAR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD89
Function Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Cellular Location Isoform A.1: Cell membrane; Single-pass type I membrane protein Isoform A.3: Cell membrane; Single-pass type I membrane protein Isoform B-delta-S2: Secreted.
Tissue Location Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. EMBL; X54150; CAA38089.1; -; mRNA EMBL; X87767; CAA61039.1; -; Genomic_DNA EMBL; X87768; CAA61039.1; JOINED; Genomic_DNA EMBL; X87769; CAA61039.1; JOINED; Genomic_DNA EMBL; X87766; CAA61039.1; JOINED; Genomic_DNA EMBL; X87765; CAA61039.1; JOINED; Genomic_DNA EMBL; U43774; AAC50639.1; -; mRNA EMBL; U43677; AAC50595.1; -; mRNA EMBL; U56236; AAB00566.1; -; mRNA EMBL; U56237; AAB00567.1; -; mRNA EMBL; S82919; AAD14421.1; -; mRNA EMBL; D87853; BAA13471.1; -; mRNA EMBL; D87854; BAA13472.1; -; mRNA EMBL; D87855; BAA13473.1; -; mRNA EMBL; D87856; BAA13474.1; -; mRNA EMBL; D87857; BAA13475.1; -; mRNA EMBL; D87859; BAA13477.1; -; mRNA EMBL; D87861; BAA13479.1; -; mRNA EMBL; D87862; BAA13480.1; -; mRNA EMBL; DQ075334; AAZ76577.1; -; mRNA EMBL; DQ075335; AAZ76578.1; -; mRNA EMBL; DQ075336; AAZ76579.1; -; mRNA EMBL; DQ075337; AAZ76580.1; -; mRNA EMBL; DQ075338; AAZ76581.1; -; mRNA EMBL; DQ075339; AAZ76582.1; -; mRNA EMBL; AC011501; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC027953; AAH27953.1; -; mRNA CCDS; CCDS12907.1; -. [P24071-1] CCDS; CCDS12908.1; -. [P24071-3] CCDS; CCDS12909.1; -. [P24071-10] CCDS; CCDS12910.1; -. [P24071-7] CCDS; CCDS42622.1; -. [P24071-2] CCDS; CCDS42623.1; -. [P24071-11] CCDS; CCDS42624.1; -. [P24071-9] CCDS; CCDS42625.1; -. [P24071-8] PIR; G02630; G02630 PIR; JH0332; JH0332 RefSeq; NP_001991.1; NM_002000.3. [P24071-1] RefSeq; NP_579803.1; NM_133269.3. [P24071-2] RefSeq; NP_579805.1; NM_133271.3. [P24071-3] RefSeq; NP_579806.1; NM_133272.3. [P24071-10] RefSeq; NP_579807.1; NM_133273.3. [P24071-9] RefSeq; NP_579808.1; NM_133274.3. [P24071-8] RefSeq; NP_579811.1; NM_133277.3. [P24071-7] RefSeq; NP_579812.1; NM_133278.3. [P24071-11] UniGene; Hs.659872; - PDB; 1OVZ; X-ray; 3.00 A; A/B=22-216 PDB; 1OW0; X-ray; 3.10 A; C/D=22-216 PDB; 1UCT; X-ray; 2.10 A; A=21-229 PDBsum; 1OVZ; - PDBsum; 1OW0; - PDBsum; 1UCT; - DisProt; DP00311; - ProteinModelPortal; P24071; - SMR; P24071; - BioGrid; 108498; 5 IntAct; P24071; 3 STRING; 9606.ENSP00000347714; - GuidetoPHARMACOLOGY; 2991; - MEROPS; I43.951; - iPTMnet; P24071; - PhosphoSitePlus; P24071; - BioMuta; FCAR; - DMDM; 119860; - PaxDb; P24071; - PeptideAtlas; P24071; - PRIDE; P24071; - ProteomicsDB; 54181; - ProteomicsDB; 54182; -. [P24071-10] ProteomicsDB; 54183; -. [P24071-11] ProteomicsDB; 54184; -. [P24071-2] ProteomicsDB; 54185; -. [P24071-3] ProteomicsDB; 54186; -. [P24071-4] ProteomicsDB; 54187; -. [P24071-5] ProteomicsDB; 54188; -. [P24071-6] ProteomicsDB; 54189; -. [P24071-7] ProteomicsDB; 54190; -. [P24071-8] ProteomicsDB; 54191; -. [P24071-9] DNASU; 2204; - Ensembl; ENST00000345937; ENSP00000338257; ENSG00000186431. [P24071-3] Ensembl; ENST00000353758; ENSP00000338058; ENSG00000186431. [P24071-7] Ensembl; ENST00000355524; ENSP00000347714; ENSG00000186431. [P24071-1] Ensembl; ENST00000359272; ENSP00000352218; ENSG00000186431. [P24071-10] Ensembl; ENST00000391723; ENSP00000375603; ENSG00000186431. [P24071-8] Ensembl; ENST00000391724; ENSP00000375604; ENSG00000186431. [P24071-11] Ensembl; ENST00000391725; ENSP00000375605; ENSG00000186431. [P24071-2] Ensembl; ENST00000391726; ENSP00000375606; ENSG00000186431. [P24071-9] Ensembl; ENST00000469767; ENSP00000473814; ENSG00000186431. [P24071-4] Ensembl; ENST00000488066; ENSP00000474512; ENSG00000186431. [P24071-5] Ensembl; ENST00000610340; ENSP00000477610; ENSG00000275136. [P24071-8] Ensembl; ENST00000610397; ENSP00000480965; ENSG00000275269. [P24071-3] Ensembl; ENST00000610786; ENSP00000483121; ENSG00000276858. [P24071-8] Ensembl; ENST00000611018; ENSP00000484483; ENSG00000275970. [P24071-11] Ensembl; ENST00000611130; ENSP00000484917; ENSG00000273738. [P24071-11] Ensembl; ENST00000611871; ENSP00000482976; ENSG00000273738. [P24071-10] Ensembl; ENST00000611943; ENSP00000482273; ENSG00000275564. [P24071-2] Ensembl; ENST00000612150; ENSP00000478233; ENSG00000275136. [P24071-3] Ensembl; ENST00000612159; ENSP00000484662; ENSG00000276985. [P24071-9] Ensembl; ENST00000612505; ENSP00000479792; ENSG00000276985. [P24071-8] Ensembl; ENST00000612803; ENSP00000478454; ENSG00000275970. [P24071-8] Ensembl; ENST00000612815; ENSP00000483503; ENSG00000275269. [P24071-8] Ensembl; ENST00000612918; ENSP00000482056; ENSG00000274580. [P24071-3] Ensembl; ENST00000613199; ENSP00000478465; ENSG00000276858. [P24071-1] Ensembl; ENST00000613201; ENSP00000482108; ENSG00000274580. [P24071-4] Ensembl; ENST00000613298; ENSP00000482451; ENSG00000275269. [P24071-9] Ensembl; ENST00000613318; ENSP00000481560; ENSG00000273738. [P24071-4] Ensembl; ENST00000613663; ENSP00000483437; ENSG00000275564. [P24071-4] Ensembl; ENST00000613685; ENSP00000481230; ENSG00000275564. [P24071-11] Ensembl; ENST00000614226; ENSP00000483099; ENSG00000276985. [P24071-1] Ensembl; ENST00000614298; ENSP00000483472; ENSG00000275970. [P24071-9] Ensembl; ENST00000614433; ENSP00000480748; ENSG00000276985. [P24071-2] Ensembl; ENST00000614689; ENSP00000480013; ENSG00000273738. [P24071-5] Ensembl; ENST00000614893; ENSP00000477966; ENSG00000273738. [P24071-2] Ensembl; ENST00000614917; ENSP00000479831; ENSG00000275970. [P24071-2] Ensembl; ENST00000614954; ENSP00000479924; ENSG00000276858. [P24071-9] Ensembl; ENST00000615040; ENSP00000477656; ENSG00000276858. [P24071-10] Ensembl; ENST00000615110; ENSP00000484276; ENSG00000274580. [P24071-2] Ensembl; ENST00000615361; ENSP00000482741; ENSG00000273738. [P24071-9] Ensembl; ENST00000615703; ENSP00000484868; ENSG00000275136. [P24071-4] Ensembl; ENST00000615719; ENSP00000482518; ENSG00000275136. [P24071-7] Ensembl; ENST00000615800; ENSP00000483841; ENSG00000276985. [P24071-4] Ensembl; ENST00000615829; ENSP00000482623; ENSG00000274580. [P24071-1] Ensembl; ENST00000615937; ENSP00000478075; ENSG00000274580. [P24071-11] Ensembl; ENST00000616340; ENSP00000481676; ENSG00000275269. [P24071-10] Ensembl; ENST00000616878; ENSP00000480970; ENSG00000275136. [P24071-9] Ensembl; ENST00000616969; ENSP00000479039; ENSG00000275564. [P24071-5] Ensembl; ENST00000617025; ENSP00000481129; ENSG00000276985. [P24071-3] Ensembl; ENST00000617609; ENSP00000481394; ENSG00000274580. [P24071-10] Ensembl; ENST00000617696; ENSP00000482670; ENSG00000274580. [P24071-9] Ensembl; ENST00000617762; ENSP00000484136; ENSG00000276858. [P24071-5] Ensembl; ENST00000617766; ENSP00000479230; ENSG00000275269. [P24071-4] Ensembl; ENST00000617778; ENSP00000480498; ENSG00000273738. [P24071-3] Ensembl; ENST00000617964; ENSP00000484141; ENSG00000275564. [P24071-7] Ensembl; ENST00000618271; ENSP00000484741; ENSG00000276985. [P24071-7] Ensembl; ENST00000618287; ENSP00000481668; ENSG00000275564. [P24071-10] Ensembl; ENST00000618328; ENSP00000480496; ENSG00000276985. [P24071-10] Ensembl; ENST00000618658; ENSP00000479688; ENSG00000275970. [P24071-4] Ensembl; ENST00000618805; ENSP00000481985; ENSG00000275269. [P24071-2] Ensembl; ENST00000618985; ENSP00000480323; ENSG00000275269. [P24071-5] Ensembl; ENST00000619073; ENSP00000479360; ENSG00000273738. [P24071-8] Ensembl; ENST00000619155; ENSP00000480461; ENSG00000275970. [P24071-5] Ensembl; ENST00000619385; ENSP00000482334; ENSG00000275269. [P24071-1] Ensembl; ENST00000619414; ENSP00000478163; ENSG00000276858. [P24071-2] Ensembl; ENST00000619822; ENSP00000483250; ENSG00000275136. [P24071-2] Ensembl; ENST00000620162; ENSP00000483258; ENSG00000276858. [P24071-11] Ensembl; ENST00000620179; ENSP00000478315; ENSG00000278415. [P24071-7] Ensembl; ENST00000620270; ENSP00000482022; ENSG00000276985. [P24071-11] Ensembl; ENST00000620397; ENSP00000477584; ENSG00000276985. [P24071-5] Ensembl; ENST00000620801; ENSP00000481195; ENSG00000275970. [P24071-1] Ensembl; ENST00000620822; ENSP00000483327; ENSG00000275269. [P24071-7] Ensembl; ENST00000620873; ENSP00000479099; ENSG00000275269. [P24071-11] Ensembl; ENST00000621004; ENSP00000484816; ENSG00000275970. [P24071-10] Ensembl; ENST00000621009; ENSP00000482025; ENSG00000275970. [P24071-3] Ensembl; ENST00000621289; ENSP00000481366; ENSG00000275136. [P24071-5] Ensembl; ENST00000621417; ENSP00000478634; ENSG00000274580. [P24071-5] Ensembl; ENST00000621684; ENSP00000479239; ENSG00000276858. [P24071-3] Ensembl; ENST00000621702; ENSP00000482807; ENSG00000275136. [P24071-1] Ensembl; ENST00000621755; ENSP00000484906; ENSG00000275970. [P24071-7] Ensembl; ENST00000621882; ENSP00000484272; ENSG00000274580. [P24071-7] Ensembl; ENST00000622157; ENSP00000481502; ENSG00000275564. [P24071-1] Ensembl; ENST00000622470; ENSP00000477673; ENSG00000276858. [P24071-7] Ensembl; ENST00000622491; ENSP00000477643; ENSG00000274580. [P24071-8] Ensembl; ENST00000622543; ENSP00000483402; ENSG00000275564. [P24071-3] Ensembl; ENST00000622646; ENSP00000480406; ENSG00000273738. [P24071-7] Ensembl; ENST00000622737; ENSP00000479738; ENSG00000273738. [P24071-1] Ensembl; ENST00000622777; ENSP00000481345; ENSG00000275136. [P24071-10] Ensembl; ENST00000622883; ENSP00000479880; ENSG00000276858. [P24071-4] Ensembl; ENST00000622904; ENSP00000480444; ENSG00000275136. [P24071-11] Ensembl; ENST00000638206; ENSP00000492749; ENSG00000284061. [P24071-3] Ensembl; ENST00000638212; ENSP00000492230; ENSG00000284061. [P24071-1] Ensembl; ENST00000638238; ENSP00000492629; ENSG00000283750. [P24071-11] Ensembl; ENST00000638242; ENSP00000492364; ENSG00000283750. [P24071-8] Ensembl; ENST00000638244; ENSP00000492699; ENSG00000283953. [P24071-7] Ensembl; ENST00000638285; ENSP00000491595; ENSG00000284061. [P24071-8] Ensembl; ENST00000638290; ENSP00000492003; ENSG00000283750. [P24071-9] Ensembl; ENST00000638453; ENSP00000491493; ENSG00000284061. [P24071-4] Ensembl; ENST00000638527; ENSP00000491362; ENSG00000284245. [P24071-2] Ensembl; ENST00000638553; ENSP00000491372; ENSG00000284004. [P24071-7] Ensembl; ENST00000638625; ENSP00000492755; ENSG00000283953. [P24071-9] Ensembl; ENST00000638882; ENSP00000492226; ENSG00000283953. [P24071-3] Ensembl; ENST00000638900; ENSP00000491778; ENSG00000283953. [P24071-8] Ensembl; ENST00000638906; ENSP00000492268; ENSG00000283750. [P24071-7] Ensembl; ENST00000638945; ENSP00000492228; ENSG00000284245. [P24071-9] Ensembl; ENST00000638966; ENSP00000491307; ENSG00000283953. [P24071-11] Ensembl; ENST00000638995; ENSP00000491741; ENSG00000284004. [P24071-3] Ensembl; ENST00000639014; ENSP00000491039; ENSG00000284245. [P24071-8] Ensembl; ENST00000639163; ENSP00000491556; ENSG00000284061. [P24071-7] Ensembl; ENST00000639178; ENSP00000492137; ENSG00000284061. [P24071-2] Ensembl; ENST00000639193; ENSP00000491447; ENSG00000284004. [P24071-2] Ensembl; ENST00000639223; ENSP00000492274; ENSG00000284061. [P24071-10] Ensembl; ENST00000639337; ENSP00000491914; ENSG00000283750. [P24071-3] Ensembl; ENST00000639392; ENSP00000492068; ENSG00000283750. [P24071-2] Ensembl; ENST00000639402; ENSP00000492442; ENSG00000284245. [P24071-1] Ensembl; ENST00000639426; ENSP00000492415; ENSG00000284004. [P24071-10] Ensembl; ENST00000639428; ENSP00000491642; ENSG00000284061. [P24071-11] Ensembl; ENST00000639455; ENSP00000491849; ENSG00000284061. [P24071-9] Ensembl; ENST00000639575; ENSP00000492321; ENSG00000283953. [P24071-2] Ensembl; ENST00000639763; ENSP00000491420; ENSG00000284004. [P24071-8] Ensembl; ENST00000640025; ENSP00000492529; ENSG00000283750. [P24071-10] Ensembl; ENST00000640032; ENSP00000492077; ENSG00000284004. [P24071-9] Ensembl; ENST00000640047; ENSP00000490997; ENSG00000284245. [P24071-7] Ensembl; ENST00000640063; ENSP00000491889; ENSG00000284004. [P24071-11] Ensembl; ENST00000640070; ENSP00000491192; ENSG00000283750. [P24071-4] Ensembl; ENST00000640239; ENSP00000492762; ENSG00000283953. [P24071-1] Ensembl; ENST00000640405; ENSP00000491490; ENSG00000284004. [P24071-1] Ensembl; ENST00000640415; ENSP00000491274; ENSG00000284245. [P24071-10] Ensembl; ENST00000640430; ENSP00000492494; ENSG00000283953. [P24071-4] Ensembl; ENST00000640462; ENSP00000491298; ENSG00000284245. [P24071-3] Ensembl; ENST00000640562; ENSP00000492074; ENSG00000283750. [P24071-5] Ensembl; ENST00000640582; ENSP00000492447; ENSG00000283750. [P24071-1] Ensembl; ENST00000640584; ENSP00000491818; ENSG00000284061. [P24071-5] Ensembl; ENST00000640618; ENSP00000491815; ENSG00000284245. [P24071-5] Ensembl; ENST00000640687; ENSP00000492597; ENSG00000283953. [P24071-5] Ensembl; ENST00000640761; ENSP00000492411; ENSG00000284004. [P24071-4] Ensembl; ENST00000640811; ENSP00000492678; ENSG00000283953. [P24071-10] Ensembl; ENST00000640878; ENSP00000492686; ENSG00000284245. [P24071-11] Ensembl; ENST00000640908; ENSP00000492162; ENSG00000284245. [P24071-4] Ensembl; ENST00000640918; ENSP00000491746; ENSG00000284004. [P24071-5] GeneID; 2204; - KEGG; hsa:2204; - UCSC; uc002qhq.4; human. [P24071-1] CTD; 2204; - DisGeNET; 2204; - EuPathDB; HostDB:ENSG00000186431.18; - GeneCards; FCAR; - HGNC; HGNC:3608; FCAR HPA; HPA014050; - MIM; 147045; gene neXtProt; NX_P24071; - OpenTargets; ENSG00000186431; - PharmGKB; PA28055; - eggNOG; ENOG410IG5T; Eukaryota eggNOG; ENOG4111BK0; LUCA GeneTree; ENSGT00760000119033; - HOGENOM; HOG000234395; - HOVERGEN; HBG004337; - InParanoid; P24071; - KO; K06513; - OMA; VENWHSH; - OrthoDB; EOG091G0FVY; - PhylomeDB; P24071; - TreeFam; TF336644; - Reactome; R-HSA-6798695; Neutrophil degranulation ChiTaRS; FCAR; human EvolutionaryTrace; P24071; - GeneWiki; FCAR; - GenomeRNAi; 2204; - PRO; PR:P24071; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000186431; - CleanEx; HS_FCAR; - ExpressionAtlas; P24071; baseline and differential Genevisible; P24071; HS GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc GO; GO:0005886; C:plasma membrane; IDA:CAFA GO; GO:0035579; C:specific granule membrane; TAS:Reactome GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome GO; GO:0019862; F:IgA binding; IDA:CAFA GO; GO:0019766; F:IgA receptor activity; IDA:CAFA GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:CAFA GO; GO:0035457; P:cellular response to interferon-alpha; IDA:CAFA GO; GO:0071346; P:cellular response to interferon-gamma; IDA:CAFA GO; GO:0071354; P:cellular response to interleukin-6; IDA:CAFA GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:CAFA GO; GO:0071356; P:cellular response to tumor necrosis factor; IDA:CAFA GO; GO:0038093; P:Fc receptor signaling pathway; IDA:CAFA GO; GO:0006955; P:immune response; TAS:ProtInc GO; GO:0042119; P:neutrophil activation; IDA:CAFA GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome GO; GO:0002446; P:neutrophil mediated immunity; IDA:CAFA GO; GO:0033031; P:positive regulation of neutrophil apoptotic process; IDA:CAFA GO; GO:1903209; P:positive regulation of oxidative stress-induced cell death; IDA:CAFA Gene3D;; -; 2 InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR003599; Ig_sub SMART; SM00409; IG; 2 SUPFAM; SSF48726; SSF48726; 2 1: Evidence at protein level; 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; IgA-binding protein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix SIGNAL 1 21 CHAIN 22 287 Immunoglobulin alpha Fc receptor /FTId=PRO_0000015138 TOPO_DOM 22 227 Extracellular. TRANSMEM 228 246 Helical. TOPO_DOM 247 287 Cytoplasmic. DOMAIN 42 107 Ig-like C2-type 1 DOMAIN 139 200 Ig-like C2-type 2 CARBOHYD 65 65 N-linked (GlcNAc...) asparagine CARBOHYD 79 79 N-linked (GlcNAc...) asparagine CARBOHYD 141 141 N-linked (GlcNAc...) asparagine CARBOHYD 177 177 N-linked (GlcNAc...) asparagine CARBOHYD 186 186 N-linked (GlcNAc...) asparagine CARBOHYD 198 198 N-linked (GlcNAc...) asparagine DISULFID 49 100 {ECO:0000244|PDB:1OVZ, ECO:0000244|PDB:1OW0, ECO:0000244|PDB:1UCT, ECO:0000269|PubMed:12768205, ECO:0000269|PubMed:12783876} DISULFID 146 193 {ECO:0000244|PDB:1OVZ, ECO:0000244|PDB:1OW0, ECO:0000244|PDB:1UCT, ECO:0000269|PubMed:12768205, ECO:0000269|PubMed:12783876} VAR_SEQ 12 23 Missing (in isoform B-delta-S2, isoform L10, isoform U09, isoform U10, isoform U11 and isoform U13) /FTId=VSP_002632 VAR_SEQ 24 120 Missing (in isoform L10) /FTId=VSP_043565 VAR_SEQ 24 24 G -> GRYISEHFWCRSLGCNPVNDASAQRPG (in isoform U02) /FTId=VSP_002633 VAR_SEQ 115 210 Missing (in isoform U10) /FTId=VSP_043566 VAR_SEQ 121 216 Missing (in isoform A.3) /FTId=VSP_002634 VAR_SEQ 193 287 CYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAV AGLVLVALLAILVENWHSHTALNKEASADVAEPSWSQQMCQ PGLTFARTPSVCK -> LHPPRLHDAELDPHGRGRTGPRGS LGHTG (in isoform U09) /FTId=VSP_043567 VAR_SEQ 195 216 Missing (in isoform A.2, isoform U02 and isoform U13) /FTId=VSP_002635 VAR_SEQ 217 287 DSIHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNK EASADVAEPSWSQQMCQPGLTFARTPSVCK -> GRYRPVQ PCVWVGCPGPCHRAGI (in isoform B and isoform B-delta-S2). /FTId=VSP_002636 VARIANT 113 113 D -> N (in dbSNP:rs11666735) /FTId=VAR_049996 VARIANT 269 269 S -> G (in dbSNP:rs16986050) /FTId=VAR_049997 HELIX 23 25 {ECO:0000244|PDB:1UCT} STRAND 31 35 {ECO:0000244|PDB:1UCT} STRAND 37 40 {ECO:0000244|PDB:1UCT} STRAND 45 49 {ECO:0000244|PDB:1UCT} STRAND 56 64 {ECO:0000244|PDB:1UCT} STRAND 67 70 {ECO:0000244|PDB:1UCT} STRAND 72 74 {ECO:0000244|PDB:1UCT} STRAND 77 79 {ECO:0000244|PDB:1OVZ} STRAND 84 87 {ECO:0000244|PDB:1UCT} HELIX 92 94 {ECO:0000244|PDB:1UCT} STRAND 96 104 {ECO:0000244|PDB:1UCT} TURN 105 107 {ECO:0000244|PDB:1UCT} STRAND 108 111 {ECO:0000244|PDB:1UCT} STRAND 115 120 {ECO:0000244|PDB:1UCT} STRAND 127 132 {ECO:0000244|PDB:1UCT} STRAND 134 136 {ECO:0000244|PDB:1UCT} STRAND 143 147 {ECO:0000244|PDB:1UCT} STRAND 149 151 {ECO:0000244|PDB:1UCT} STRAND 154 160 {ECO:0000244|PDB:1UCT} STRAND 168 171 {ECO:0000244|PDB:1UCT} STRAND 173 179 {ECO:0000244|PDB:1UCT} HELIX 185 187 {ECO:0000244|PDB:1UCT} STRAND 189 196 {ECO:0000244|PDB:1UCT} STRAND 198 200 {ECO:0000244|PDB:1OVZ} STRAND 211 215 {ECO:0000244|PDB:1UCT} SEQUENCE 287 AA; 32265 MW; A2CCA68467CD45F7 CRC64; MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
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This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.


Vuong, M.T., et al. Kidney Int. (2010) In press :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Peng, M., et al. Cell Res. 20(2):223-237(2010)
Kobayashi, T., et al. J. Dent. Res. 88(12):1137-1141(2009)
van der Steen, L., et al. Gastroenterology 137(6):2018-2029(2009)

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