|Application ||WB, E|
|Other Accession||P85834, Q8BFR5, NP_003312.3|
|Calculated MW||49542 Da|
|Antigen Region||342-370 aa|
|Other Names||Elongation factor Tu, mitochondrial, EF-Tu, P43, TUFM|
|Target/Specificity||This TUFM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 342-370 amino acids from the C-terminal region of human TUFM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TUFM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17.
Valente, L., et al. Biochim. Biophys. Acta 1792(8):791-795(2009)
Sasarman, F., et al. Hum. Mol. Genet. 17(23):3697-3707(2008)
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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