|Application ||WB, E|
|Other Accession||Q687Y7, NP_002181.1|
|Calculated MW||17504 Da|
|Antigen Region||61-87 aa|
|Other Names||Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17|
|Target/Specificity||This IL17A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human IL17A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL17A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).|
|Tissue Location||Restricted to activated memory T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Chen, X., et al. Cancer Sci. 101(11):2384-2390(2010)
Dart, M.L., et al. Circ. Res. 107(9):1106-1116(2010)
Marwaha, A.K., et al. J. Immunol. 185(7):3814-3818(2010)
Crome, S.Q., et al. J. Immunol. 185(6):3199-3208(2010)
Weng, X.M., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 24(1):42-44(2010)
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