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ACVR1B AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP12925a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP12925a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ACVR1B Antibody - Product info | |
| Application | WB, IHC
|
| Primary Accession | P36896 |
| Other Accession | NP_004293.1, NP_064733.3 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 56807 Da |
ACVR1B Antibody - Additional info | |
| Gene ID 91 | |
| Other Names ACVR1B; ACVRLK4; ALK4; Activin receptor type-1B; Activin receptor type IB; Activin receptor-like kinase 4; Serine/threonine-protein kinase receptor R2 | |
| Target/Specificity This ACVR1B antibody is generated from rabbits immunized with a recombinant protein from human ACVR1B. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACVR1B Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACVR1B Antibody - Protein Information | |
| Name ACVR1B | |
| Synonyms ACVRLK4, ALK4 | |
| Function Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine- threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C- terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2 | |
| Cellular Location Cell membrane; Single-pass type I membrane protein (By similarity) | |
| Tissue Location Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver | |
ACVR1B Antibody - Related products
AM1863a: ACVR1B Antibody (Ascites)
AP7801a: Activin A Receptor Type IB (ACVR1B) Antibody (N-term)
AP7801c: Activin A Receptor Type IB (ACVR1B) Antibody (Center)
RI10098: ACVR1B predesign siRNA
DC00105: Human ACVR1B cDNA Clone
LY11040a: ACVR1B Over-expression Lysate
ACVR1B Antibody - Application data
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Western blot analysis of ACVR1B (arrow) using rabbit polyclonal ACVR1B Antibody (Cat. #AP12925a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1B gene.
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ACVR1B Antibody (Cat. #AP12925a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACVR1B Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
ACVR1B Antibody - Research Areas
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BACKGROUND
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Suzuki, K., et al. Biochem. Biophys. Res. Commun. 394(3):639-645(2010) Calvanese, L., et al. J. Pept. Sci. 15(3):175-183(2009) Esguerra, C.V., et al. Development 134(24):4381-4393(2007) Maguire, P.B., et al. Proteomics 2(6):642-648(2002)
