|Application ||WB, E|
|Other Accession||NP_009028.1, NP_001825.1|
|Calculated MW||25190 Da|
|Other Names||Clathrin light chain B, Lcb, CLTB|
|Target/Specificity||This CLTB antibody is generated from rabbits immunized with a recombinant protein from human CLTB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLTB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|
|Cellular Location||Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles|
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Provided below are standard protocols that you may find useful for product applications.
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)
Loerke, D., et al. Traffic 6(10):918-929(2005)
Chen, C.Y., et al. J. Biol. Chem. 280(7):6109-6117(2005)
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