|Application ||WB, IHC-P, FC, E|
|Other Accession||Q7SZT7, O09032, Q61701, P26378, Q91584, Q60900, Q14576, Q91903, Q8CH84, Q60899, NP_001164666.1, NP_001164668.1|
|Predicted||Mouse, Rat, Xenopus|
|Calculated MW||39504 Da|
|Antigen Region||156-184 aa|
|Other Names||ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB|
|Target/Specificity||This ELAVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human ELAVL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELAVL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.|
|Tissue Location||Brain; neural-specific.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.
Marroni, F., et al. Circ Cardiovasc Genet 2(4):322-328(2009)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
D'Alessandro, V., et al. Cell. Oncol. 30(4):291-297(2008)
Jonson, L., et al. Mol. Cell Proteomics 6(5):798-811(2007)
Yano, M., et al. J. Biol. Chem. 280(13):12690-12699(2005)
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