|Application ||WB, IHC-P, E|
|Calculated MW||97415 Da|
|Antigen Region||838-866 aa|
|Other Names||Plakophilin-2, PKP2|
|Target/Specificity||This PKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 838-866 amino acids from the C-terminal region of human PKP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PKP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13.
Fressart, V., et al. Europace 12(6):861-868(2010)
Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
Christensen, A.H., et al. Cardiology 115(2):148-154(2010)
den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009)
Bhuiyan, Z.A., et al. Circ Cardiovasc Genet 2(5):418-427(2009)
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